Volume 24, Spring 2014
Vishal Saxena, Joshua A. Gordon
Dedication to Dr. Ernest J. Gentchos
Vishal Saxena, Joshua A. Gordon
Letter from the Dedicated
Ernest J. Gentchos
Letter from the Chairman
L. Scott Levin
Letter from the Program Director
Craig L. Israelite
Clinical Articles
Penn Presbyterian Medical Center Hip and Knee Risk Reduction Program Overview
Eric L. Hume, Atul F. Kamath, P. Maxwell Courtney, Finnah Pio, Laura Kosseim, Craig L. Israelite
Multimodal Analgesia for Total Joint Arthroplasty
Rosemary MG Hogg, Jiabin Liu, Eric Hume, Nabil M. Elkassabany
An Analysis of the Demographic and Technical Characteristics Associated with Iliac Cortical Perforation During Insertion of Iliosacral Screws
J. Stuart Melvin, Nicholas Pulos, Keith Baldwin, Amer Mirza, Michael J. Gardner, Samir Mehta
Safety of Bilateral Total Knee Arthroplasty: Simultaneous Versus Staged at a Week Interval
P. Maxwell Courtney, Christopher M. Melnic, Hassan Alosh, Roshan P. Shah, Charles L. Nelson, Craig L. Israelite
Strategies and Application of Ankle-Spanning Multiplanar External Fixators
Ryan M. Taylor, Matthew P. Sullivan, Derek J. Donegan, Jaimo Ahn, Samir Mehta
Length, Alignment, and Rotation: Operative Techniques for Intramedullary Nailing of the Comminuted, Diaphyseal Femur Fracture
Matthew P. Sullivan, Ryan M. Taylor, Derek J. Donegan, Samir Mehta, Jaimo Ahn
Treatment of Thumb Basal Joint Arthritis With Hematoma and Distraction Arthroplasty Compared to LRTI in a Predominantly Male Population
Stephen Y. Liu, Christina F. Endress, David R. Steinberg
Functional Knee Outcomes in Suprapatellar and Infrapatellar Tibial Nailing: Does Approach Matter?
P. Maxwell Courtney, Anthony Boniello, Derek J. Donegan, Jaimo Ahn, Samir Mehta
Anterior Hip Dislocation Five Months After Hip Arthroscopy: A Case Report and Review of the Literature
Daniel C. Austin, John G. Horneff III, John D. Kelly IV
Intraoperative Use of Rib-to-Pelvis Traction to Correct Pelvic Obliquity in the Neuromuscular Spine
Martin J. Morrison III, John M. Flynn
Arthroscopic-Assisted Reduction and Buttress Fixation of Tibial Plateau Fracture Using a Bioabsorbable Interference Screw
Pramod B. Voleti, Surena Namdari, John D. Kelly IV
Balanced Cranial Suspension for Intraoperative Correction of Cervical Kyphosis
Michael T. Talerico, Venus Vakhshori, Andrew H. Milby, Adam T. Griska, Harvey E. Smith, Vincent M. Arlet
Idiopathic Avulsion Fractures of the Lesser Trochanter in Pediatric Patients
Christine M. Goodbody, Wudbhav N. Sankar
Core Decompression Surgery for Avascular Necrosis Can Delay Femoral Head Collapse in Patients with Sickle Cell Disease: A Case Report
Afamefuna Nduaguba, Christine Goodbody, Wudbhav N. Sankar, Lawrence Wells
Operative Technique:Arthroscopic Repair of Massive Rotator Cuff Tears
Michael H. McGraw, John D. Kelly IV
Displaced Inferior Ramus Fractures as a Marker for Pelvic Instability
P. Maxwell Courtney, Ryan M. Taylor, John Scolaro, Derek J. Donegan, Samir Mehta
Alternative Protocol for Heterotopic Ossification Prophylaxis in Posterior Approaches for Acetabulum Fractures
Deren T. Bagsby, Karl Shively, Brian H. Mullis
EOS Imaging: Insight Into This Emerging Musculoskeletal Imaging System
Emmanouil Grigoriou, Saba Pasha, John P. Dormans
For Patients With Impingement Syndrome, is the Acromion Innocent?
Shawn Bifano, Kevin B. Freedman, Joseph Bernstein, Fotios Tjoumakaris
Basic Science
Biomechanics of Ligament and Tendon
Overuse Following a Large Rotator Cuff Tear Alters Trabecular Bone Architecture but Not Glenoid Curvature in a Rat Model
Michael W. Hast, Sarah Yannascoli, George W. Fryhofer, Wei-Ju Tseng, Allison Altman, X. Sherry Liu, Louis J. Soslowsky
Collagen V Null Mice Have Decreased ACL Mechanical Properties and Altered Fibril Morphology
Brianne K. Connizzo, Benjamin R. Freedman, Mei Sun, David E. Birk, Louis J. Soslowsky
Evaluating Changes in Tendon Crimp with Fatigue Loading as an Ex Vivo Structural Assessment of Tendon Damage
Benjamin R. Freedman, Andrey Zuskov, Joseph J. Sarver, Mark R. Buckley, Akash Kumar, Louis J. Soslowsky
Scapular Dyskinesis is Detrimental to Shoulder Tendon Properties and Joint Mechanics in a Rat Model
Katherine E. Reuther, Stephen J. Thomas, Jennica J. Tucker, Sarah M. Yannascoli, Adam C. Caro, Rameen P. Vafa, Andrew F. Kuntz, Louis J. Soslowsky
The Effect of Type II Diabetes on Native Mechanical and Biologic Shoulder Joint Properties in a Rat Model
Stephen J. Thomas, Joseph J. Sarver, Sarah Yannascoli, Jennica J. Tucker, John D. Kelly IV, Rexford A. Ahima, Mary F. Barbe, Louis J. Soslowsky
Exercise Protocol Induces Muscle,Tendon, and Bone Adaptations in the Rat Shoulder
Sarah I. Rooney, Emanuele Loro, Joseph J. Sarver, Cathryn D. Peltz, Michael W. Hast, Wei-Ju Tseng, X. Sherry Liu, Tejvir S. Khurana, Louis J. Soslowsky
Intra-Articular Tibiofemoral Injection of a Nonsteroidal Anti-Inflammatory Drug has no Detrimental Effects on Joint Mechanics in a Rat Model
Corinne N. Riggin, Jennica J. Tucker, Louis J. Soslowsky, Andrew F. Kuntz
Alterations in the Mechanical Properties of Patellar Tendons in Bone Sialoprotein-Null Mice
Andrey Zuskov, Andrew A. Dunkman, Yohannes Soenjaya, Benjamin R. Freedman, Louis J. Soslowsky, Harvey A. Goldberg
Musculoskeletal Tissue Engineering
Trajectory-Based Tissue Engineering for Cartilage Repair: Impact of Maturation State and Rate on Integration Potential
Matthew B. Fisher, Nicole Soegaard, Elizabeth A. Henning, George R. Dodge, David R. Steinberg, Robert L. Mauck
Enhanced Nutrient Transport Improves Depth-Dependent Properties of a Tri-layered HA Construct With Zonal Co-culture of Chondrocytes and MSCs
Minwook Kim, Jason A. Burdick, Robert L. Mauck
A Radiopaque Electrospun Scaffold for Engineering Fibrous Tissues: Characterization and In Vivo Application
John T. Martin, Andrew H. Milby, Subash Poudel, Christian G. Pfeifer, Harvey E. Smith, Dawn M. Elliott, Robert L. Mauck
Validation and Screening in a High Throughput Mechanical Injury Model of Engineered Cartilage
Bhavana Mohanraj, Greg R. Meloni, Rodolfo Finocchi, Robert L. Mauck, George R. Dodge
Material-Mediated Degradation of the Meniscus Wound Interface Enhances Integration
Feini Qu, Michael P. Pintauro, Elizabeth A. Henning, John L. Esterhai, Matthew B. Fisher, Robert L. Mauck
Maturation and Material Dependent Response of AF and NP Cells to Mechanical Perturbation
Dong Hwa Kim, Lachlan J. Smith, Dawn M. Elliott, Robert L. Mauck
Enhanced Integration with Treatment of Sprifermin (rhFGF18) in a Cartilage Injury-Repair Model
Alexandra JE Farran, Ryan A. Cocca, Gregory Meloni, Bhavana Mohanraj, Anne Gigout, Robert L. Mauck, George R. Dodge
Perlecan Expression is Strongly Reduced in Aging Cartilage but Increased by Physiological Loading
Ryan A. Cocca, Arjan van Caam, Alexandra Farran, Bhavana Mohanraj, Gregory Meloni, Robert L. Mauck, Peter M. van der Kraan, George R. Dodge
Stem Cell Mechanobiology
Rapid and Sustained Changes in Nuclear Architecture and Mechanics in Mesenchymal Stem Cells in Response to Dynamic Stretch
Su-Jin Heo, Stephen Thorpe, Tristan P. Driscoll, Sohaib K. Hashmi, David A. Lee, Robert L. Mauck
Inherent and Emergent Heterogeneity in Clonal Stem Cell Populations
Brian D. Cosgrove, Megan J. Farrell, Margaret Dunagin, Claire M. McLeod, Allison J. Cote, Arjun Raj, Robert L. Mauck
Engineered Fiber Crimp Alters Scaffold Mechanics, Cell Shape, and Strain Transfer to the Nucleus
Tristan P. Driscoll, Jefferson Chang, Ty’Quish S. Keyes, Michael W. Hast, Su-Jin Heo, Robert L. Mauck, Pen-Hsiu Grace Chao
Fracture Healing
Bone Morphogenetic Protein and Fractures:A Meta-Analysis
Mara L. Schenker, Sarah M. Yannascoli, Derek J. Donegan, Keith D. Baldwin, Jaimo Ahn, Samir Mehta
Deficient Geriatric Fracture Healing is Associated with Alterations in Immune Cell Function and Cell Cycle
Luke A. Lopas, Lee McDaniel, Nicole S. Belkin, Patricia L. Mutyaba, Derek Dopkin, Kurt D. Hankenson, Jaimo Ahn
Local Activation of Notch Signaling Enhances Geriatric Bone Regeneration
Patrick N. Domerchie, Derek Dopkin, Kurt D. Hankenson, Jaimo Ahn
Cartilage and Bone Biology
Enhanced Individual Trabecular Repair and its Mechanical Implications in PTH and Alendronate Treated Rat Tibial Bone
Allison R. Altman, Chantal M. de Bakker, Abhishek Chandra, Beom Kang Huh, Ling Qin, X. Sherry Liu
Delayed Chondrocyte Differentiation and Altered Indian Hedgehog Signaling Contribute to Failed Vertebral Bone Formation in Mucopolysaccharidosis VII
Chelsea M. del Alcazar, Joseph A. Chiaro, Eileen M. Shore, Mark E. Haskins, Lachlan J. Smith
Deep Sequencing of Notochord-Derived Cells During Embryonic Formation of the Nucleus Pulposus: Preliminary Findings
Lachlan J. Smith, Joseph A. Chiaro, Kendra K. McKee, Neil R. Malhotra, Robert L. Mauck, Brian D. Harfe
Changes in the Trabeculae-Vessel Function Unit in Response to Estrogen Deficiency-Induced Bone Loss and Intermittent Parathyroid Hormone-Induced Bone Gain
Wei-Ju Tseng, Tiao Lin, Chantal MJ de Bakker, L. Scott Levin, Ling Qin, X. Sherry Liu
Alendronate and PTH Combination Therapy Stimulates Bone Formation While Inhibiting Bone Resorption Activities in the Rat Tibia:A Longitudinal, In Vivo, Dynamic Bone Histomorphometry Study
Chantal M. de Bakker, Allison Altman, Connie Li, Wei-Ju Tseng, Mary Beth Tribble, Beom Kang Huh, Abhishek Chandra, Ling Qin, X. Sherry Liu
Alleviation of Radiotherapy-Induced Local Trabecular Bone Loss by PTH(1-34) is Associated with Improved DNA Repair and Cell Survival in Osteoblasts
Abhishek Chandra, Tiao Lin, Ji Zhu, Beom Kang Huh, Allison Altman, Sarah Hagan, Keith Cengel, X. Sherry Liu, Ling Qin
Comparison Between Ovariectomy and Lactation Induced Bone Loss:A Dynamic Imaging Study
Connie Li, Carina Lott, Allison R. Altman, Chantal M. de Bakker, X. Sherry Liu
Increased Endocortical Formation and Periosteal Resorption in Premenopausal Women with Idiopathic Osteoporosis Treated with Intermittent Parathyroid Hormone
Mary Beth Tribble, Adi Cohen, Chantal M. de Bakker, Kyle Nishiyama, Elizabeth Shane, X. Sherry Liu
Translational Animal Models
Development of a Large Animal Model of Osteochondritis Dissecans (OCD) of the Knee
Christian G. Pfeifer, Stuart D. Kinsella, Andrew H. Milby, Matthew B. Fisher, Nicole S. Belkin, Robert L. Mauck, James L. Carey
Healing Response and Subchondral Bone Remodeling with Treatment of Focal Cartilage Lesions in a Porcine Model
Matthew B. Fisher, Nicole S. Belkin, Andrew R. Milby, Elizabeth A. Henning, George R. Dodge, David R. Steinberg, Robert L. Mauck
Percutaneous Delivery of Chondroitinase ABC Induces Moderate Disc Degeneration in a Goat Model
Andrew H. Milby, Brent L. Showalter, Joanne Haughan, Robert L. Mauck, Dawn M. Elliott, Neil R. Malhotra, Thomas P. Schaer, Lachlan J. Smith
A Rat Model for Elbow Allotransplantation
Scott M. Tintle, Juyu Tang, L. Scott Levin
Heterotopic Ossification
Gain-of-Function Alk2 Mutation Enhances Chondrocyte Differentiation and Promotes Heterotopic Endochondral Ossification
Andria L. Culbert, Salin A. Chakkalakal, Robert J. Caron, Eileen M. Shore
Heterozygous Inactivation of Gnas Induces Heterotopic Ossification and Impairs Normal Skeletal Development
Girish Ramaswamy, Deyu Zhang, Frederick S. Kaplan, Robert J. Pignolo, Eileen M. Shore
Editorials
“Together We Build” – Penn Orthopaedics and the Philadelphia 76ers
Brian J. Sennett
Clinical Research Update
Annamarie D. Horan
Penn Orthopaedics in Nicaragua
Ryan M. Taylor, Jaimo Ahn, Samir Mehta
Penn Orthopaedics in Trinidad
Nicole S. Belkin, Vincent M. Arlet
From the Penn Orthopaedics Human Tissue Lab
Joshua A. Gordon
Penn Microsurgical Skills Cadaver Course for Hand Fellows and Residents
T. Shane Johnson, Joshua A. Gordon, L. Scott Levin
International Congress for Joint Reconstruction Inaugural Philadelphia Revision Arthroplasty Course
James E. Murphy, Joshua A. Gordon
Administrative Chief Residents’ Perspective
Mara Schenker, Adam Griska, Chancellor Gray
Penn Orthopaedics Service Summary: 2013 at a Glance
Lori Gustave, Fabian Marechal, Ryan Gonzales
A Tribute to Anthony (Tony) Searles
Frederick S. Kaplan
Health System Updates
Hospital of the University of Pennsylvania
John L. Esterhai, Jaimo Ahn, Derek Donegan, Keith Baldwin, Kristy Weber, L. Scott Levin, Samir Mehta
Penn Presbyterian Medical Center
David J. Bozentka
Pennsylvania Hospital
Neil P. Sheth
The Children’s Hospital of Philadelphia
John P. Dormans, Ashley Trocle
Philadelphia Veterans Affairs Medical Center
John L. Esterhai
Bayhealth Medical Center
Christos D. Photopoulos, Stephen G. Manifold
McKay Orthopaedic Research Laboratory
Louis J. Soslowsky
The PVAMC Translational Musculoskeletal Research Center is “Open for Business”
Robert L. Mauck, George R. Dodge
Building Our Tomorrow
Alyson Cole