Volume 23, Spring 2013
Letter from the Editors-in-Chief
Yannascoli SM, Milby AH
Dedication to Dr. R. Bruce Heppenstall
Yannascoli SM, Milby AH
Letter from the Dedicated
Heppenstall RB
Letter from the Chairman
Levin LS
Letter from the Program Director
Israelite CL
Clinical Articles
Hand
Bilateral Hand Transplantation, a “Life-Saving” Operation?: A Case Report and Commentary
Tintle SM, Levin LS
Interfacility Transfer Utilization in the Management Pediatric Hand Injuries
Milby AH, Gunderson M, Gornitzky A, Chang B, Carrigan RB
Pediatrics
The Genetic Nature of Osteochondritis Dissecans: A Systematic Review and Call for Improved Studies
Gans I, Ganley TJ
Operative Technique: Pediatric All-Epiphyseal Anterior Cruciate Ligament Reconstruction with Quadrupled Semitendinosus Autograft
Sarkissian EJ, Ganley TJ
Tibial Eminence Fractures: A Review and Algorithm for Treatment
Gans I, Ganley TJ
Spine
Four-Rod Constructs for Complex Spinopelvic Reconstruction
Milby AH, Slaughter JB, Smith HE, Arlet VM
C3-C4 Unilateral Facet Fracture Dislocation with Vertebral Artery Injury in an Adolescent: A Case Report, Review of the Literature, and Suggested Management Protocol
Kulkarni SS, O’Toole PO, Storm PB, Gunderson M, Wells L, Drummond DS
Review of Patient Reported Outcome Measures used in Pediatric Spinal Deformity Surgery
Harshavardhana NS, Dormans JP
Shoulder and Elbow
Do Diabetes and Hypertension Precede the Development of Adhesive Capsulitis?
Austin DC, Gans I, Park MJ, Carey JL, Kelly JD
Concurrent Ipsilateral Total Elbow Arthroplasty and Reverse Total Shoulder Arthroplasty: A Case Report and Review of the Literature
Horneff JG, Huffman GR
Arthroscopic Localization of the Coracohumeral Ligament
McHale KJ, Park MJ, Garcia G, Kelly JD
Sports Medicine
Operative Technique: Arthroscopic Remplissage
McHale KJ, Park MJ, Kelly JD
Pediatric ACL Injury Prevention: Improving Strength and Performance with a Prevention Program
Sarkissian EJ, Albaugh JD, Ganley TJ
Adult Reconstruction
Functional Recovery following Ceramic-on-Ceramic Total Hip Arthroplasty in Patients Younger than Fifty-Five Years of Age
Shah RP, Scolaro JA, Componovo R, Garino JP, Nelson CL, Lee GC
Long Tapered Hydroxyapatite-Coated Stems in Revision Total Hip Arthroplasty
Makani A, Kim TWB, Garino JP, Lee GC
Trauma
The Cost of After-Hours Operative Debridement of Open Tibia Fractures
Schenker ML, Ahn J, Donegan DJ, Mehta S, Baldwin KD
Operative Technique: Scapula Fractures
Voleti PB, Namdari S, Mehta S
Blowing Smoke: A Meta-Analysis of the Effects of Smoking on Fracture Healing and Postoperative Infection
Schenker ML, Scolaro JA, Yannascoli SM, Baldwin KD, Mehta S, Ahn J
General
How to Write a Systematic Review: A Step-by-Step Guide
Yannascoli SM, Schenker ML, Carey JL, Ahn J, Baldwin KD
Practitioner Bias in the Interpretation of the Effects of Resident Work Hour Restrictions
Baldwin KD, Namdari S, Tjoumakaris F, Mehta S
Mentorship in Orthopaedics
Harshavardhana NS, Colo D, Dormans JP
Nanotechnology: Translational Applications in Orthopaedic Surgery
McHale KJ, Sullivan MP, Mehta S
Basic Science
Tendon Injury and Repair
Location-Specific Changes in Flexor Carpi Ulnaris Tendon Mechanical Properties in the Absence of Biglycan or Decorin
Buckley MR, Huffman GR, Iozzo RV, Birk DE, Soslowsky LJ
Effects of Decorin and Biglycan on Re-Alignment and Mechanical Properties of Aging Supraspinatus Tendons
Connizzo BK, Birk DE, Iozzo RV, Soslowsky LJ
Dynamic Mechanical Properties of Tendon Repair Tissue are Unaffected by Aging
Dunkman AA, Buckley MR, Mienaltowski MJ, Kumar A, Beason DP, Pathmanathan L, Birk DE, Soslowsky LJ
Injured Achilles Tendon Exhibits Inferior Mechanical and Structural Response During Fatigue Loading
Freedman BR, Sarver JJ, Voleti PB, Buckley MR, Soslowsky, LJ
Achilles Tendon Repair Response to Injury is Enhanced by the Absence of Decorin
Ilkhani-Pour S, Voleti PB, Buckley MR, Freedman BR, Iozzo R, Birk DE, Soslowsky LJ
Biceps Mechanical Properties Are Not Altered in the Presence of Asymptomatic Rotator Cuff Tendon Tears
Reuther KE, Thomas SJ, Satchell LN, Soslowsky LJ
Supraspinatus and Infraspinatus Rotator Cuff Repair Prevents Mechanical Damage to the Intact Subscapularis Tendon in a Rat Model
Reuther KE, Feeney E, Tucker JJ, Voleti PB, Glaser DL, Soslowsky LJ
Biceps Detachment Does Not Worsen Shoulder Function in a Multi-Tendon Rotator Cuff Tear Rat Model
Thomas SJ, Reuther KE, Sarver JJ, Tucker J, Satchell L, Glaser DL, Soslowsky LJ
Musculoskeletal Tissue Engineering
Hyaluronic Acid Hydrogels for Articular Cartilage Defect Repair in a Large Animal Model
Belkin NS, Fisher MB, Henning EA, Kim M, Bian L, Burdick JA, Steinberg DR, Mauck RL
Trajectory-based Tissue Engineering for Cartilage Repair: A Methodology to Better Predict In-Vivo Success
Fisher MB, Soegaard N, Henning EA, Dodge GR, Steinberg DR, Mauck RL
Mesenchymal Stem Cell-Based Cartilage is Unstable in Very Long Term In-Vitro Culture
Farrell MJ, Fisher MB, Soegaard N, Farrell KM, Mauck RL
An Inverse Agonist for Retinoic Acid Receptors Boosts Mesenchymal Stem Cell Chondrogenesis and Functional Properties of Tissue Engineered Cartilage
Farrell MJ, Chiaro JA, Henning EA, Pacifici M, Mauck RL
A High Throughput Mechanical Model to Study Injurious Compression of Engineered Cartilage
Mohanraj B, Hou C, Schmidt MM, Cosgrove BD, Mauck RL, Dodge GR
Depth-Dependent Properties of a Tri-layered Hyaluronic Acid Hydrogel Construct with Zonal Co-culture of Chondrocytes and MSCs
Kim M, Farrell MJ, Burdick JA, Mauck RL
Mesenchymal Stem Cells in Chondrogenic 3D Culture Are More Sensitive to Pro-Inflammatory Cytokines than Chondrocytes
Mohanraj B, Schmidt MM, Dodge GR, Mauck RL
Improved Meniscus Integration via Controlled Degradation of the Wound Interface
Qu F, Lin JG, Esterhai JL, Fisher MB, Mauck RL
Effects of Low Oxygen Tension on the Biomechanical Properties, Composition and mRNA Expression of Engineered Nucleus Pulposus
Gorth DJ, Chiaro JA, Dodge GR, Hebela NM, Elliott DM, Mauck RL, Smith LJ
Stem Cell Mechanobiology
Dynamic Stretch Rapidly Alters Nuclear Structure and Increases Chromatin Condensation in Mesenchymal Stem Cells
Heo S, Thorpe SD, Driscoll TP, Hashmi SK, Lee DA, Mauck RL
Cytoskeletal Tension is Required for Dynamic Tensile Loading Induced Alterations in Mesenchymal Stem Cell Shape and Nuclear Connectivity
Driscoll TP, Shurden ZE, Heo S, Mauck RL
Nanofiber Length Scale Differentially Impacts Meniscus and Mesenchymal Stem Cell Morphology and Nuclear Deformation
Silverstein AM, Heo S, Mauck RL
Fracture Healing
Disruption of Thrombospondin-2 Accelerates Ischemic Fracture Healing
Miedel EL, Dopkin D, Yu Y, Ahn J, Miclau T, Marcucio R, Hankenson K
A Mouse Model of Geriatric Fracture Healing: Toward the Elucidation of Aged Fracture Healing Deficiencies
Belkin NS, Lopas LA, Karp MR, Dopkin D, Dishowitz MI, Williams A, Mutyaba PL, Hankenson K, Ahn J
Bone Biology and Microarchitecture
A Closer Look at the Immediate Trabeculae Response to Combined Parathyroid Hormone and Alendronate Treatment
Altman A, Huh B, Luo S, Chandra A, Qin L, Liu X
3D Image Registration Is Critical to Ensure Accurate Detection of Longitudinal Changes in Bone Microstructure and Mineral Density Measurements in Rats by In Vivo Micro Computed Tomography
Luo S, Lan S, Chandra A, Huh B, Altman A, Qin L, Liu X
Fibrodysplasia Ossificans Progressiva
The FOP R206H Alk2 Mutation Enhances BMP-Induced Chondrogenic Differentiation
Culbert AC, Chakkalakal SA, Caron RJ, Shore EM
Functional Consequences of Fibrodysplasia Ossificans Progressiva-associated Mutations ACVR1R206H and ACVR1Q207E in Comparison to Constitutive Active ACVR1Q207D
Haupt J, Deichsel A, Stange K, Kajikhina E, Ast C, Souidi N, Kaplan FS, Shore EM, Seeman P
Editorials
Penn Orthopaedics in Nicaragua
Griska AT, Ahn J
Departmental Items
Health System Updates
Hospital of the University of Pennsylvania
Levin LS
Penn Presbyterian Medical Center
Bozentka DJ
Pennsylvania Hospital
Arlet VM
Children’s Hospital of Philadelphia
Dormans JP
Philadelphia Veterans Affairs Medical Center
Esterhai JL
McKay Orthopaedic Research Laboratory
Soslowsky LJ